In 1988, Wilson and his band-mates were inducted into the Rock and Roll Hall of Fame, which refers to Wilson on its website as "One of the few undisputed geniuses in popular music". In 2008, Rolling Stone magazine published a list of the "100 Greatest Singers of All Time", and ranked Wilson number 52. Wilson won a Grammy Award in 2005 for "Mrs. O'Leary's Cow (Fire)" as Best Rock Instrumental. He is also an occasional actor and voice actor, having appeared in television shows, films, and other music artist music videos.

Wilson was born June 20, 1942 at Centinela Hospital in Inglewood, California. He was the eldest of three boys; his younger brothers were Dennis and Carl. When Brian was two, the Wilson family moved from Inglewood to 3701 West 119th Street in nearby Hawthorne, California, a town in the greater Los Angeles urban area about five miles inland from the Pacific Ocean. He spent his entire subsequent childhood years in this middle-class family home.

Brian Wilson's father Murry Wilson told of Brian's unusual musical abilities prior to his first birthday, observing that the baby could repeat the melody from "When the Caissons Go Rolling Along" after only a few verses had been sung by the father. Murry stated, "He was very clever and quick. I just fell in love with him."

At about age two, Brian heard George Gershwin's "Rhapsody in Blue", which had an enormous emotional impact on him. A few years later Brian was discovered to have extremely diminished hearing in his right ear. The exact cause of this hearing loss is unclear, though theories range from Brian's simply being born partially deaf, to a blow to the head from Brian's father, or a neighborhood bully, being to blame.

While father Murry was ostensibly a reasonable provider, he was abusive and hard to please, liable to dispense harsh punishments for minor or perceived misdeeds. But Murry, a minor musician and songwriter, also encouraged his children in this field in numerous ways. At a young age, Brian was given six weeks of lessons on a "toy accordion", and at seven and eight sang solos in church with a choir behind him.

By most accounts a natural leader by the time he began attending Hawthorne High School, Brian was on the football team as a quarterback, played baseball and was a cross-country runner in his senior year. However, most of his energy was directed toward music. He sang with various students at school functions and with his family and friends at home. Brian taught his two brothers harmony parts that all three would then practice when they were supposed to be asleep. He also played piano obsessively after school, deconstructing the harmonies of The Four Freshmen by listening to short segments of their songs on a phonograph, then working to recreate the blended sounds note by note on the keyboard. Brian received a Wollensak tape recorder on his sixteenth birthday, allowing him to experiment with recording songs and early group vocals.

Wilson's surviving home tapes document his initial musical efforts singing with various buddies and family, including a song that would later be recorded in the studio by The Beach Boys, "Sloop John B", as well as "Bermuda Shorts" and a hymn titled "Good News". In his senior year at Hawthorne High, in addition to his classroom music studies, he would gather at lunchtime to sing with friends like Keith Lent and Bruce Griffin. Brian and Lent worked on a revised version of the tune "Hully Gully" to support the campaign of a classmate named Carol Hess who was running for senior class president. When performed for a full high school gathering, Brian's revised arrangement received a warm round of applause from the student audience.

Enlisting his cousin and often-time singing partner Mike Love, and Wilson's reluctant youngest brother Carl Wilson, Brian's next public performance featured more ambitious arrangements at a fall arts program at his high school. To entice Carl into the group, Wilson named the newly-formed membership "Carl and the Passions". The performance featured tunes by Dion and the Belmonts and The Four Freshmen ("It's a Blue World"), the latter of which proved difficult for the ensemble to carry off. However, the event was notable for the impression it made on another musician and classmate of Brian's who was in the audience that night, Al Jardine, later to join the three Wilson brothers and Mike Love in The Beach Boys.

Brian enrolled at El Camino Community College in Los Angeles, majoring in psychology, in September 1960. However, he continued his music studies at the college as well. At some point in the year 1961 Brian wrote his first all-original melody, loosely based on a Dion and the Belmonts version of "When You Wish Upon a Star". Brian's tune would eventually be known as "Surfer Girl". Brian has commented that he wrote the melody in his car, then later at home finished the bridge and harmonies. Although an early demo of the song was recorded in Feb. 1962 at World-Pacific Studios, it was not re-recorded and released until 1963, when it became a top ten hit.

Brian and his brothers Carl and Dennis Wilson along with Mike Love and Al Jardine first gelled as a music group in the summer of 1961, initially named the Pendletones. After being prodded by Dennis to write a song about the local water sports craze, Brian and Mike Love together created what would become the first single for the band, "Surfin'". Recorded by Hite and Dorinda Morgan and released on the small Candix label, the song became a top local hit in Los Angeles and reached number seventy-five on the national Billboard sales charts.